NAD+
Solid foundational science on NAD+'s cellular roles, but human clinical evidence remains extremely limited. The research is mostly theoretical extrapolation from what we know about aging biology.
Studied primarily by aging researchers and mitochondrial biologists investigating cellular energy decline and longevity interventions.
Since Feb 2026
30 total, 1 human
What is NAD+?
This essential coenzyme has caught researchers' attention as a potential anti-aging intervention, despite not actually being a peptide. NAD+ drives fundamental cellular processes that deteriorate with age, making it a target for longevity studies. Injectable formulations have emerged from peptide vendors to circumvent the poor oral absorption that limits supplementation effectiveness.
NAD+ functions as a crucial helper molecule that mitochondria need to convert nutrients into cellular energy, while also powering enzymes called sirtuins that regulate aging processes and DNA repair systems. Think of it as both the fuel delivery system and the maintenance crew for your cells - when NAD+ levels drop with age, energy production falters and cellular repair mechanisms slow down.
What the Research Shows
Despite 30 studies in the database, only one involved human subjects, leaving a significant gap between promising laboratory findings and clinical reality.
Notable Studies
Yang F, Deng X, Yu Y et al. · Front Endocrinol (Lausanne) (2022)
Cohort · n=1 · ,518
Borsky P, Holmannova D, Andrys C et al. · Biogerontology (2023)
Cohort · n=169
Bruinsma BG, Avruch JH, Sridharan GV et al. · Transplantation (2017)
Cohort · n=19
Li F, Wang Y, Zheng K · Autophagy (2023)
Case Series
Yang X, Zhang X, Tian Y et al. · Circ Res (2025)
Animal
Reported Benefits
Combinations & Interactions
Regulatory Status
Last verified: Feb 2026
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This information is for research purposes only and does not constitute medical advice. Always consult a licensed physician before using any peptides.