GLUTATHIONE
One of the most thoroughly researched peptides with robust human clinical data spanning decades. Evidence strongly supports its antioxidant and detoxification roles, though administration method matters significantly.
Widely studied in liver disease research, dermatology trials for skin lightening, and clinical toxicology for heavy metal chelation and acetaminophen overdose treatment.
Since Feb 2026
30 total, 28 human
What is GLUTATHIONE?
Often called the body's most important antioxidant, this simple three-amino acid molecule plays essential roles in cellular defense and liver detoxification. Research focuses heavily on injectable formulations since the peptide breaks down rapidly in the digestive tract, making oral supplements largely ineffective.
This tripeptide works as a cellular janitor, directly scavenging harmful reactive oxygen species while also regenerating depleted antioxidants like vitamin C and vitamin E back to their active forms. It serves as a critical cofactor in the liver's Phase II detoxification pathways, helping conjugate and eliminate toxins, while also maintaining the reduced state necessary for proper immune cell function.
What the Research Shows
Strong evidence base with 28 human studies including multiple randomized controlled trials, though many focus on specific disease states rather than general health enhancement.
Notable Studies
Yaikwawong M, Jansarikit L, Jirawatnotai S et al. · Nutrients (2024)
RCT · n=22712 · months
Gómez-Gavara C, Moya-Herraiz Á, Hervás D et al. · Transplantation (2021)
RCT · n=214 · February 2012 to January 2016
Lane HY, Wang SH, Lin CH · Psychiatry Clin Neurosci (2023)
RCT · n=14924 · weeks
Wallis RS, Sabi I, Lalashowi J et al. · NEJM Evid (2024)
RCT · n=140168 · days
Duperray J, Sergheraert R, Chalothorn K et al. · J Cosmet Dermatol (2022)
RCT · n=12412 · weeks
Reported Benefits
Regulatory Status
Last verified: Feb 2026
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This information is for research purposes only and does not constitute medical advice. Always consult a licensed physician before using any peptides.