SYN-AKE
Zero human studies published despite widespread use in cosmetics. The evidence consists entirely of lab-based testing.
Cosmetic chemists and anti-aging product manufacturers incorporate it into creams and serums marketed as botox alternatives.
Since Feb 2026
0 total
What is SYN-AKE?
Temple viper venom inspired this synthetic tripeptide that's become a popular ingredient in anti-aging skincare products. The cosmetic industry markets it heavily as 'snake venom cream,' claiming it can smooth wrinkles by temporarily paralyzing facial muscles. Research labs and cosmetic companies study it as a topical alternative to botulinum toxin injections.
The peptide blocks nerve signals that tell facial muscles to contract by interfering with nicotinic acetylcholine receptors at nerve-muscle junctions. Think of it like jamming the communication line between your brain and your face muscles — when applied to skin, the theory is that reduced muscle movement leads to fewer expression lines and wrinkles.
What the Research Shows
No published human trials exist, with available data limited to computational modeling and basic laboratory experiments.
The evidence base for SYN-AKE consists of a single study with no human trials or randomized controlled trials conducted to date. Available data are limited to computational and laboratory testing demonstrating anti-aging activity in non-clinical models.
Notable Studies
Gok B, Budama-Kilinc Y, Kecel-Gunduz S · J Biomol Struct Dyn (2024)
In Vitro
Reported Benefits
Regulatory Status
Last verified: Feb 2026
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This information is for research purposes only and does not constitute medical advice. Always consult a licensed physician before using any peptides.